- Chronic stress leading to the constant release of cortisol, the stress hormone; and blood sugar fluctuations causing frequent big spikes in the hormone insulin
The constant release of these hormones can lead to insensitivity as the body gets used to them and they no longer perform their action well, good examples of this are insulin insensitivity and type II diabetes (National institute of diabetes and digestive and kidney diseases) and cortisol insensitivity and burn out.
Insulin and cortisol work synergistically to keep glucose levels balanced, if they aren’t working well due to dietary choices and chronic stress it can soon lead to problems. (Diabetes UK)
In this scenario, the negative feedback loop mentioned earlier will start to impact other hormones, such as the sex hormones; oestrogen, progesterone and testosterone, and as a result further ill health/symptoms experienced. (Tsigos et al 2020)
- Endocrine disruptors (EDC) from chemicals, food and plastics that mimic or block hormones from their receptors (National institute of environmental sciences)
Dr Shanna Swan, an environmental and reproductive epidemiologist, published a research paper in 2017 that looked at sperm count from 1973 to 2011. It concluded that during this time period ‘sperm count has dropped by 59%’ and this is due to the endocrine disrupting chemicals that surround us. Dr Swan has predicted that by 2045 ‘most couples may have to use assisted reproduction’ due to these chemicals.
Pesticide action network UK (PAN UK) stated in April 2024 that these chemicals are called ‘forever chemicals’. They are described as this because ‘of their ability to persist in the environment and accumulate in the blood, bones and tissue of living organisms’ and it takes them ‘from a decade to 1000 years to degrade’.
They are very prevalent and ‘found in household products, non-stick cookware and plastics but also in certain pesticides which then make it into human bodies via diet’.