This review article explores the impact of periodontal therapy on systemic diseases and condition outcomes. The conclusions are based on randomized controlled trials published between 2010 and 2016. The evaluation included adverse pregnancy outcomes, diabetes, pneumonia, and chronic obstructive pulmonary disease. Due to lack of research matching the inclusion criteria, it did not include atherosclerosis, rheumatoid arthritis, Alzheimer´s disease, chronic kidney diseases or malignant neoplasia.