This systematic review is based on 59 articles, including 6724 patients in total, who were diagnosed with stage IV periodontitis (i.e., the same periodontal variables as stage III and missing ≥5 teeth). Stage IV patients often suffer from functional impairment and need oral rehabilitation, and these patients were either partially or fully edentulous. The aim was to evaluate the effect of bridges or dentures versus no treatment from the perspective of oral health related quality of life and systemic health.